Preston North End thumped Scunthorpe United 4-0 after two Joe Garner goals, a Chris Humphrey strike and a Miguel Angel Llera own goal saw the visitors run away the winners.
Tottenham Hotspur loanee Kenneth McEvoy and a Kyle Vassell brace helped Peterborough come back from a goal down to beat MK Dons in a five-goal thriller.
Oldham Athletic's summer signing Jonathan Forte continued his rich form in front of goal, scoring his third goal in two games. However, it wasn't enough as Leyton Orient responded with three goals to take all three points.
Ben Williamson, Tom Pope and Carl Dickinson all got on the scoresheet for Port Vale as Doncaster had a terrible day at the office as Harry Forrester received a red card for Rovers.
Chesterfield's match with Rochdale saw three penalties, with Eoin Doyle converting both of the home side's spot kicks to give the Spireites the victory.
An Aaron Wilbraham brace was enough to see off an early George Moncur strike as Bristol City get their second win of the season.
A late Robert Harris goal was enough to separate Coventry and Sheffield United as the Blades pick up another defeat and remain without a point in the League One table.
Barnsley fought from a goal down to beat Crewe Alexandra 2-1 thanks to Leroy Lita and Martin Cranie strikes in the second half.
A Louis Thompson red card resulted in a second-half Izale McLeod penalty for Crawley which condemned Swindon Town to their first defeat of the season after beating Scunthorpe on the first day of the new campaign.
Gillingham comfortably beat Yeovil Town 2-0 thanks to Joe Martin and Danny Kedwell strikes either side of half time.
Jamie Proctor scored his second goal in as many games earning Fleetwood Town an away win against Notts County.
The only goalless draw of the day in League One went to Walsall and Bradford with both teams unable to find the back of the net.
Results in full: Bristol City 2-1 Colchester United, Chesterfield 2-1 Rochdale, Coventry City 1-0 Sheffield United, Crawley Town 1-0 Swindon Town, Crewe Alexandra 1-2 Barnsley, Doncaster Rovers 1-3 Port Vale, Gillingham 2-0 Yeovil Town, Notts County 0-1 Fleetwood Town, Oldham Athletic 1-3 Leyton Orient, Peterborough United 3-2 MK Dons, Scunthorpe United 0-4 Preston North End, Walsall 0-0 Bradford City
